Figure 4 | Scientific Reports

Figure 4

From: miR-139-5p Inhibits the Epithelial-Mesenchymal Transition and Enhances the Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating BCL2

Figure 4

miR-139-5p enhances chemotherapeutic sensitivity in colon cancer cells.

(A,B) miR-139-5p expression significantly enhanced the sensitivity of HCT116 to 5-FU and OXA and significantly reduced their IC50 based on the CCK-8 assay. (C) miR-139-5p-transfected cells showed greater sensitivity towards 5-FU and OXA, with more cells undergoing apoptosis after the treatment (*P > 0.05, **P < 0.05).

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