Figure 6 | Scientific Reports

Figure 6

From: miR-139-5p Inhibits the Epithelial-Mesenchymal Transition and Enhances the Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating BCL2

Figure 6

Re-expression of BCL2 abolishes miR-139-5p-induced inhibition of colon cancer metastasis and drug sensitivity.

(A,B) Western blot and RT-PCR analysis of BCL2 protein expression in HCT116 colon cancer cells expressing miR-139-5p or miR-139-5p plus BCL2. Reintroduction of BCL2 reversed the effects of miR-139-5p on cell migration and invasion (C,D) and drug sensitivity (E). Each sample was repeated three times. *, **P < 0.05.

Back to article page