Figure 6: Repeated treatment with MAP induced a release of dopamine in the nucleus accumbens of Gomafu KO mice. | Scientific Reports

Figure 6: Repeated treatment with MAP induced a release of dopamine in the nucleus accumbens of Gomafu KO mice.

From: Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine

Figure 6

The extracellular concentration of dopamine (DA) in the nucleus accumbens of freely moving WT or Gomafu KO mice was measured by in vivo microdialysis and high-performance liquid chromatography. Five basal fractions were collected before the administration of MAP. After treatment with MAP (1 mg/kg, i.p) at time 0, 6 fractions were collected every 20 minutes. Dopamine concentration was expressed as a percentage of the average of values of the 5 baseline fractions obtained. Data are represented as the means and standard errors of the mean for the indicated numbers (n) of mice, 5 for each genotype. The p-value from two-way repeated-measures ANOVA for each test (10–120 min, WT vs KO) is presented. (A) Dopamine concentration after a single treatment. (B) Dopamine concentration after repeated treatment.

Back to article page