Table 3 Association between CHRNA7 SNPs and LOAD by APOE ε4 status.

From: CHRNA7 Polymorphisms and Dementia Risk: Interactions with Apolipoprotein ε4 and Cigarette Smoking

Haplotype block

SNP/Haplotype (frequency among controls)

0 copies

1 or 2 copies

P interaction

Case/Control

AOR

Case/Control

AOR (95% CI)

1

SNP1

All

76/145

1.00

178/290

1.48 (0.94–2.32)

0.23

  

APOE ε4 (−)

44/121

1.00

110/247

1.25 (0.73–2.13)

 
  

APOE ε4 (+)

31/24

1.00

68/41

2.10 (0.89–4.94)

 

1

SNP2

All

182/348

1.00

68/84

1.53 (0.93–2.52)

0.69

  

APOE ε4 (−)

111/294

1.00

40/71

1.52 (0.84–2.75)

 
  

APOE ε4 (+)

70/52

1.00

28/13

1.68 (0.63–4.42)

 

2

SNP3

All

95/179

1.00

157/255

1.16 (0.76–1.79)

0.62

  

APOE ε4 (−)

59/155

1.00

94/212

1.26 (0.76–2.09)

 
  

APOE ε4 (+)

35/23

1.00

63/42

0.84 (0.35–2.02)

 

3

SNP4

All

77/139

1.00

176/293

1.50 (0.73–1.82)

0.59

  

APOE ε4 (−)

48/125

1.00

105/241

1.22 (0.72–2.09)

 
  

APOE ε4 (+)

28/14

1.00

71/50

0.84 (0.32–2.21)

 

3

SNP5

All

115/225

1.00

134/205

1.34 (0.88–2.04)

0.15

  

APOE ε4 (−)

64/189

1.00

51/35

1.59 (0.97–2.61)

 
  

APOE ε4 (+)

87/175

1.00

46/29

0.79 (0.35–1.81)

 

3

SNP6

All

109/181

1.00

143/253

0.79 (0.51–1.21)

0.82

  

APOE ε4 (−)

75/161

1.00

79/207

0.79 (0.48–1.29)

 
  

APOE ε4 (+)

34/20

1.00

63/44

0.65 (0.26–1.62)

 

3

SNP7

All

88/160

1.00

165/274

1.10 (0.72–1.71)

0.23

  

APOE ε4 (−)

48/135

1.00

105/232

1.30 (0.77–2.20)

 
  

APOE ε4 (+)

40/24

1.00

59/41

0.73 (0.32–1.66)

 

4

SNP8

All

219/352

1.00

32/78

0.50 (0.28–0.92)

0.03

  

APOE ε4 (−)

135/298

1.00

16/66

0.29(0.13–0.64)*

 
  

APOE ε4 (+)

83/52

1.00

16/12

1.32 (0.45–3.87)

 

4

SNP9

All

143/260

1.00

110/174

1.07 (0.70–1.64)

0.10

  

APOE ε4 (−)

93/221

1.00

60/146

0.87 (0.53–1.44)

 
  

APOE ε4 (+)

50/39

1.00

49/26

1.79 (0.78–4.07)

 

4

Hap1: AC

All

14/33

1.00

240/402

1.37 (0.59–3.23)

0.61

 

(76%)

APOE ε4 (−)

7/27

1.00

147/341

1.57 (0.56–4.41)

 
  

APOE ε4 (+)

7/6

1.00

92/59

0.99 (0.19–5.04)

 

4

Hap2: AT

All

171/319

1.00

83/116

1.34 (0.84–2.12)

0.66

 

(15%)

APOE ε4 (−)

109/271

1.00

45/97

1.28 (0.74–2.21)

 
  

APOE ε4 (+)

62/47

1.00

37/18

1.52 (0.62–3.73)

 

4

Hap3: GT

All

222/357

1.00

32/78

0.49 (0.27–0.90)

0.03

 

(9%)

APOE ε4 (−)

138/302

1.00

16/66

0.28 (0.13–0.63)*

 
  

APOE ε4 (+)

83/53

1.00

16/12

1.30 (0.44–3.83)

 
  1. All models were adjusted for age, sex, APOE ε4, and education year and conditional on 5-year age strata. Numbers in bold indicate significant findings (P < 0.05). *The association remained significant after correction for multiple tests by false discovery rate (FDR). The effects of CHRNA7 haplotypes in block1 and block3 on LOAD risk are shown in Supplementary Table S1 because the results were non-significant after correction for multiple tests. Block2 included only one htSNP and was excluded from the haplotype analysis. Abbreviations: AOR, adjusted odds ratio; CI, confidence interval; SNP, single nucleotide polymorphism; APOE, apolipoprotein E; Hap, haplotype.
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