Table 5 Polymorphisms of CHRNA7 rs7179008 and LOAD risk by smoking status.

From: CHRNA7 Polymorphisms and Dementia Risk: Interactions with Apolipoprotein ε4 and Cigarette Smoking

 

rs7179008 (SNP8)

P interaction

0 copies (AA)

1 or 2 copies (AG+GG)

Case/Control

AOR (95% CI)

Case/Control

AOR (95% CI)

Never-smokers

164/291

1.00

27/63

0.54 (0.27–1.04)

0.70

Ever-smokers

55/60

2.00 (1.03–3.87)

5/15

0.79 (0.21–2.96)

 
  1. All models were adjusted for age, sex, apolipoprotein E ε4, and education year and conditional on 5-year age strata. Numbers in bold indicate significant findings (P < 0.05). Abbreviations: AD, Alzheimer’s disease; SNP, single nucleotide polymorphism; AOR, adjusted odds ratio; CI, confidence interval.
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