Figure 2: Pre- and post-irradiation records and statistics of seizures, seizure power, coherence and background signals.

(a) Average (n = 4) normalized time/frequency maps of seizure power (time rescaled: start = 0; end = 1) recorded from the 10 electrodes (black points), before (left panel) and 1 week post-irradiation (right panel). The 4 lower maps represent the average coherence computed from the left and the right electrodes. (b) Difference of power between pre- and post-irradiation seizures: the t values are color- coded. Mediolateral coordinates are displayed by the grid overlying the brain. Time/frequency maps are normalized against the background signal preceding the seizures (duration: 5% of the seizure length). Red bars indicate the location of the transections. (c) Example of seizures recorded from the two symmetrical electrodes implanted in the transected (left) and contralateral (right) somatosensory cortex barrel fields (S1BF2) before (upper grey seizures) and 1 week after (lower red and green seizures) the transections. (d) Quantification of the mean seizure normalized power (left panel) and coherence (right panel) for the 3 central left and right electrodes before irradiation and 1, 3, 9 weeks post-irradiation. Data are expressed as percent of the baseline power/coherence of the 6–8 Hz band (*p < 0.05; **p < 0.01; Two-way repeated measure Anova, Sidak post-hoc). (e) Average fast-Fourier transforms (FFT) of background signals recorded from the left (left panel) and right electrodes (right panel) before (black histograms) and 1 week following irradiation (colored histograms). FFT amplitudes are displayed as frequency bands (delta, theta, alpha, beta, low gamma, high gamma and epsilon). There was no significant statistical differences between pre- and post-irradiation for any band (Two-way repeated measure Anova, p > 0.05).