Figure 1
BDNF-NSCs Exhibit More Therapeutic Potential than Control-NSCs to Recover the Cognitive Deficits of AD Mice.
(a) Representative pictures and scores of the nest construction test (n = 6 per group; *Non-Tg+Vehicle mice vs. Tg+Vehicle mice, #Non-Tg+Vehicle mice vs. Tg+Control-NSCs mice, $Non-Tg+Vehicle mice vs. Tg+BDNF-NSCs mice). (b) The escape latency to find the hidden platform in the MWM task (n = 12 per group; *Non-Tg mice vs. Tg+Vehicle mice, #Tg+Vehicle mice vs. Tg+Control-NSCs mice, $Tg+Vehicle mice vs. Tg+BDNF-NSCs mice, @Tg+Control-NSCs mice vs. Tg+BDNF-NSCs mice). The multiple comparisons test confirmed the significant differences between each group. (c) Representative data of the search path in the probe trial test. (d) The records of the search time in the target quadrant and the number of crosses of the probe location in the probe trial test (n = 12 per group). (e) The discrimination ratio of the novel object recognition test (discrimination index = novel object exploration time/total exploration time) (n = 12 per group). (f) ELISA for the hippocampal BDNF level (n = 12 per group). All results are presented as the mean ± SEM. * or one symbol represent p < 0.05, ** or two symbols represent p < 0.01, *** or three symbols represent p < 0.001. The data of escape latency and nest construction were analyzed by two-way ANOVAs with Bonferroni post-tests, the others were analyzed by one-way ANOVAs with Tukey’s post hoc tests.
