Table 1 Electrophysiological Properties of Transplanted Control-NSC- and BDNF-NSC-derived Neurons Generating One or More APs Upon Current Injection.

From: Gain of BDNF Function in Engrafted Neural Stem Cells Promotes the Therapeutic Potential for Alzheimer’s Disease

n

Control-NSCs

BDNF-NSCs

pvalue

16 (from 5 mice)

19 (from 7 mice)

Vrest (mV)

−74.7 ± 1.6

−73.4 ± 1.0

0.45

Rinput (MΩ)

1388 ± 326

739 ± 205

0.04

C (pF)

20.1 ± 4.1

39.9 ± 6.5

0.03

% of cell with APs

32.5 ± 15.4%

84.3 ± 10.2%

0.02

AP threshold (mV)$

−20.3 ± 1.4

−38.8 ± 2.4

0.001

AP amplitude (mV)$

56.4 ± 4.1

86.0 ± 8.0

0.03

AP half-width (ms)$

1.8 ± 0.1

1.6 ± 0.1

0.60

AHP amplitude (mV)$

8.7 ± 1.3

15.4 ± 1.2

0.01

  1. Vrest = resting membrane potential; Rinput = input resistance; C = capacitance. AP = action potential; AHP = afterhyperpolarization. Statistical analyses by the Mann-Whitney test. $Analysis based on the first AP induced by current injection.
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