Figure 1
An overview of the potential duon mutations in human cancers.
(A) A Schematic representation showing mutations in Duon elements in protein-coding regions, which have dual roles of regulating gene expression, besides coding for gene products. These mutations have the potential to perturb downstream pathways by altering both structure and expression of a gene product. (B) A schematic diagram showing the analysis pipeline. (C) The summary of potential Duon mutations in cancer genes; box with asterisk representing missense mutation. (D) Circos plot showing the genome-wide landscapes of recurrent coding mutations, including those that overlap with DNase hypersensitive cluster, transcription factor ChIP-seq peaks and altered expression of the genes that harbor them, for both lung adenocarcinoma and squamous cell carcinoma. Only DNase regions, ChIP-seq peaks overlap with recurrent mutations were shown in the plot.
