Table 2 Relation of retinal vascular calibers, presence of retinopathy and presence of microalbuminuria on risk of future cardiovascular disease event.
From: Joint Effect of Early Microvascular Damage in the Eye & Kidney on Risk of Cardiovascular Events
No. at risk | Incident cases, % | HR (95% CI) * | HR (95% CI) † | |
|---|---|---|---|---|
Retinal arteriolar caliber (μm) | ||||
Quartile 4 (151.08 − 206.31) | 876 | 28 (3.20) | Referent | Referent |
Quartile 3 (141.72 − 151.06) | 873 | 18 (2.06) | 0.63 (0.35, 1.15) | 0.75 (0.41, 1.38) |
Quartile 2 (132.08 − 141.71) | 873 | 28 (3.21) | 0.82 (0.48, 1.38) | 1.03 (0.59, 1.80) |
Quartile 1 (71.68 − 32.07) | 874 | 52 (5.95) | 1.03 (0.71, 1.80) | 1.50 (0.87, 2.58) |
P for trend | 0.328 | 0.071 | ||
per SD decrease (14.60) | 3496 | 126 (3.60) | 1.05 (0.89, 1.24) | 1.20 (0.98, 1.47) |
Retinal venular caliber (μm) | ||||
Quartile 1 (104.03−206.34) | 874 | 24 (2.75) | Referent | Referent |
Quartile 2 (206.37 − 220.11) | 874 | 27 (3.09) | 1.33 (0.77, 2.31) | 1.23 (0.69, 2.19) |
Quartile 3 (220.12 − 233.33) | 874 | 33 (3.78) | 1.05 (1.01, 3.02) | 1.64 (0.93, 2.89) |
Quartile 4 (233.34 − 296.67) | 874 | 42 (4.81) | 2.25 (1.35, 3.76) | 2.07 (1.15, 3.73) |
P for trend | 0.001 | 0.008 | ||
per SD increase (20.70) | 3496 | 126 (3.60) | 1.32 (1.13, 1.55) | 1.33 (1.09, 1.62) |
Presence of Retinopathy | ||||
No | 3189 | 101 (3.17) | Referent | Referent |
Yes | 307 | 25 (8.14) | 2.20 (1.42, 3.41) | 2.05 (1.30, 3.22) |
No. at risk | Incident cases, % | HR (95% CI) * | HR (95% CI) ‡ | |
Microalbuminuria | ||||
No | 2,991 | 81 (2.71) | Referent | Referent |
Yes | 505 | 45 (8.91) | 2.27 (1.57, 3.32) | 1.68 (1.13, 2.50) |
