Table 1 Basic information and characteristics of studies for meta-analysis.

From: Cryosurgery would be An Effective Option for Clinically Localized Prostate Cancer: A Meta-analysis and Systematic Review

Author	Year	Design	Level of evidence	Patients		Freeze-thaw cycle(s)	Mean follow up (Months)	Radiation dose/ Surgical mode	Duration of ADT ^*	Matching	Definition of recurrence	Primary or salvage
Author	Year	Design	Level of evidence	CS	RT/RP	Freeze-thaw cycle(s)	Mean follow up (Months)	Radiation dose/ Surgical mode	Duration of ADT ^*	Matching	Definition of recurrence	Primary or salvage
CS vs RT
Ball et al.⁵	2006	P	2a	39	118	Double	6	45 Gy EBRT + 100 Gy BT or 125 Gy BT (Pd -103)	NA	1, 4, 5, 6, 8	NA	Both
Hubosky et al.⁶	2007	R	3b	63	63	Double	12.7	125 Gy BT (Pd -103) or EBRT + BT	NA	1, 2, 3, 4, 5, 6, 7, 8	PSA > 0.4 ng/ml or 3 consecutive rises in PSA	Primary
Chin et al.⁷	2008	RCT	1b	33	31	Double	37	66 Gy EBRT	3 months pre- and 3 months post- treatment	1, 2, 4, 5, 6, , 8, 9	Nadir +2 ng/ml	Primary
Chin et al.⁸	2012	RCT	1b	31	31	Double	105.2	66 Gy EBRT	3 months pre- and 3 months post- treatment	1, 2, 4, 5, 6, , 8, 9	Nadir +2 ng/ml	Primary
Robinson et al.⁹	2009	RCT	1b	117	114	Double	100	<70/70/73.5 Gy EBRT	3/6 months pretreatment	1, 2, 4, 5, 6, 7, 8, 9	PSA > 0.1 ng/ml or nadir +2 ng/ml	Primary
Donnelly et al.¹⁰	2009	RCT	1b	117	114	Double	100	<70/70/73.5 Gy EBRT	3/6 months pretreatment	1, 2, 4, 5, 6, 7, 8, 9	PSA > 0.1 ng/ml or nadir +2 ng/ml	Primary
Peters et al.¹¹	2013	R	3a	54	31	Double	36 vs 108	145 Gy BT (I-125)	3 months pretreatment	1, 2, 3, 4, 5, 6, 8, 9	PSA > 0.1 ng/ml or nadir +2 ng/ml	Salvage
CS vs RP
Gould¹²	1999	R	3b	76	83	NA	25	Open	NA	1, 3, 4	PSA > 0.2 ng/ml	Primary
Pisters et al.¹³	2009	R	3b	56	42	Single and double	66 vs 93.6	NA	NA	1, 2, 4, 5, 6	PSA > 0.4 ng/ml or nadir +2 ng/ml	Salvage
Peters et al.¹¹	2013	R	3a	54	44	Double	36 vs 60	Open	≥3 months. pretreatment	1, 2, 3, 4, 5, 6, 8, 9	PSA > 0.1 ng/ml or nadir +2 ng/ml	Salvage
Elkjær et al.¹⁴	2014	P	3b	40	350	Double	29.5 vs 37	Open and robot	NA	1, 2, 3, 4, 5, 6, 7	PSA > 0.2 ng/ml or nadir +2 ng/ml	Primary

Matching: 1 = age; 2 = inclusion and exclusion criteria; 3 = stratification; 4 = PSA level; 5 = biopsy Gleason score; 6 = clinical stage; 7 = D’Amico risk group; 8 = adjuvant deprivation therapy (ADT) before treatment; 9 =ADT after treatment.
^*Not all patients had experienced adjuvant deprivation treatment (ADT) for studies have reported ADT. NA: not available; CS: cryosurgery; RT: radiotherapy; RP: radical prostatectomy; R: retrospective; P: prospective; RCT: randomized controlled trial; EBRT: external beam radiation therapy; BT: brachytherapy; PSA: prostate specific antigen; Pd: palladium; I: iodine.

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Table 1 Basic information and characteristics of studies for meta-analysis.

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