Table 3 Basic information, characteristics and outcomes from single-arm studies.

From: Cryosurgery would be An Effective Option for Clinically Localized Prostate Cancer: A Meta-analysis and Systematic Review

Author

Year

Design

Primary or salvage

Patients

Basic information

Results (%)

Mean follow-up (months)

Complications (%)

OS

DSS

bDFS

Overall

Urinary

ED

Pisters et al.20

1999

R

Salvage

145

5, 6, 7, 8, 10

55.2

>6

De La Taille et al.21

2000

P

Both

35

1, 2, 5, 6, 7, 10

100

100

70(9 months)

8.3

>8.6

Izawa et al.22

2002

R

Salvage

131

5, 6, 7, 8,

73(5 yrs)

79(5 yrs)

40(5 yrs)

57.6

  

Bahn et al.23

2002

R

Primary

590

1, 2, 5, 6, 7, 8, 10

 

89.5(7 yrs)

65.2

>15.9

56.8 increased

Prepelica et al.24

2005

R

Primary

65

1, 2, 5, 6, 7, 9, 10

100

100

83.3

35

Bahn et al.25

2006

R

Primary

31

1, 2, 6, 7

96.8

100

92.9

70

11.1(potency preservation)

Ellis et al.26

2007

NA

Primary

416

1, 5, 6, 7, 8, 9

79.6(4 yrs)

20.4

Ismail et al.27

2007

P

salvage

100

1, 2, 5, 6, 7, 8, 9, 10

100

83%(1 yr); 72%(2 yrs); 59%(3 yrs); 25%(5 yrs)

33.5

>16

86

Ng et al.28

2007

R

Salvage

187

1, 5, 6, 7, 8, 10

97 (5 yrs); 92 (8 yrs)

51

39

>39

Diblasio et al.29

2008

R

Primary

78

1, 3, 4, 5, 6, 7, 8, 10

95.9%(1 yr); 94.3(3 yrs); 94.3(5 yrs)

100

97.9%(1 yr); 82.9%(3 yrs); 82.9(5 yrs)

39.8

41 increased

33.4 increased for erectile function of 3 level and higher

Jones et al.30

2008

R

Primary

77

1, 2, 6, 7

44.6

39.0

Truesdale et al.31

2010

R

Primary

77

1,4, 6, 7, 8, 9,

72.7

24

Decreased scores according to AUA SI and IIEF-5, respectively

 

Williams et al.32

2011

R

Salvage

176

1, 5, 6, 7, 8, 10

95(5 yrs); 91(8 yrs); 87(10 yrs)

47(5 yrs); 39(8 yrs); 39(10 yrs)

89.5

Caso et al.33

2012

R

Primary

97

1, 2, 4, 5, 6, 7, 8

Biopsy: 87.6

48

Kim et al.34

2012

R

Primary

10

1, 6, 7, 9

100

100

100

13

>30

Castro Abreu et al.35

2013

R

Salvage

50

1, 6, 7, 8, 10

100

100

78 (5 yrs)

>31

Durand et al.36

2013

P

Primary

48

1, 2, 3, 6, 7, 8, 9, 10

100

100

Biopsy: 84

13.2

19

No significantdecreased

Significant decrease in 3 months but in 6 months

Al Ekish et al.37

2013

R

Both

30

1, 2, 6, 7, 9, 10

100

100

93.3

18

Hale et al.38

2013

R

Primary

26

1, 2, 4, 6, 7, 8

100

100

88.5

19.1

27 increased

Ullal et al.39

2013

R

Both

32

1, 6, 7

68.8

41.2

Li et al.40

2014

R

Salvage

91

1, 2, 6, 7, 8, 10

98.9(5 yrs)

95.3(1 yr); 72.4(3 yrs); 46.5(5 yrs)

15

>6.6

11.0 increased

Guo et al.41

2014

R

Primary

75

1, 2, 5, 6, 7, 8, 9

85.3(5 yrs)

92.0(5 yrs)

48(5 yrs)

75

Rodríguez et al.42

2014

P

Primary

102

1, 5, 6, 7, 8, 9, 10

94.4

98.1

76.9

61

>11.1

>5.6

32.1 increased

Kvorning Ternov et al.43

2014

R

Salvage

30

1, 2, 6, 7, 8, 9, 10

93.3

96.7

43.5

32.4

16.7 for grade 3 and 4

>53.3

100

Chang et al.44

2014

R

Salvage

12

1, 2, 6, 7, 8, 10

100

58.3

33

16.7

16.7

Elshafei et al.45

2015

R

Primary

2242

1, 2, 4, 5, 7, 8, 9

72.8(5yrs)

32.6

Tay et al.46

2016

R

Primary

300

1, 2, 6, 7, 8, 9, 10

96.7

77.2(2yrs), 59.1(5yrs)

28.4

>9.7

83.5

Lian et al.47

2016

R

Primary

40

1, 2, 5, 6, 7, 8, 9, 10

100

100

95

63

36.6

  1. Matching: 1 = age; 2 = inclusion and exclusion criteria; 3 = body mass index (BMI); 4 = race; 5 = stratification; 6 = PSA level; 7 = biopsy Gleason score; 8 = clinical stage; 9 = D’Amico risk group; 10 = adjuvant deprivation therapy (ADT); bDFS: biochemical disease free survival; ED: erectile dysfunction; AUA SI: American Urological Association Symptom Index; IIEF: International Index of Erectile Function; IPSS: International Prostate Symptom Score; yrs: years.