Figure 1
From: Activation of the Renin-Angiotensin System Promotes Colitis Development
Renin overexpression promotes colitis in TNBS-induced colitis model.
(A) Changes of body weight (% of original body weight) over time (day) in WT and RenTg mice following TNBS treatment. P < 0.001 by log-rank test; n = 6–8. (B) Survival curves of WT and RenTg mice following TNBS treatment; P < 0.001 by log-rank test; n = 6–16. (C) Gross morphology and macroscopic damage score of the large intestines from WT and RenTg mice on day 6 after TNBS treatment. (D) H&E staining of colon sections and colonic histological damage score for WT and RenTg mice on day 6 after TNBS treatment. Original magnification 100x. ***P < 0.001 vs. WT; n = 8–9 in each genotype. (E) Mucosal pro-inflammatory cytokine production quantified by qPCR in untreated WT and RenTg controls and on days 2 and 5 (d2 and d5) after TNBS treatment. **P < 0.01; ***P < 0.001 vs. WT.
