Figure 4
From: Activation of the Renin-Angiotensin System Promotes Colitis Development
Renin promotes colitis independently of blood pressure.
RenTg mice were pre-treated with PBS or hydralazine (10 mg/kg, i.p. daily) for one week before TNBS instillation. The treatment continued after TNBS treatment. WT mice serve as control. (A) Blood pressure changes following hydralazine treatment. **P < 0.01 vs. RenTg-PBS. n = 5–6 in each group. (B) Body weight changes (% of original body weight) on day 3; (C) Colonic macroscopic damage score; **P < 0.01; ***P < 0.001 vs. WT. n = 5–6 each group. (D) H&E staining of colon sections on day 5. Original magnification 100x.
