Figure 6

Blockade of AT1 receptor signaling ameliorates colitis in WT mice.

(A) Time course expression of mucosal AT1 receptor in TNBS-induced experimental colitis. *P < 0.05, **P < 0.01; ***P < 0.001 vs. control. (B) Body weight changes (% of original body weight) over time (days). WT mice were fed regular water or losartan-containing (10 mg/ml) water for 7 days before TNBS instillation. Losartan treatment continued following TNBS treatment for 6 days before mouse sacrifice. *P < 0.05, **P < 0.01; ***P < 0.001 vs. water, n = 6 each group. (C) Gross morphology and macroscopic damage score of the large intestines on day 6. (D) H&E staining of colon sections and histological score on day 6. Original magnification 100x. *P < 0.05; **P < 0.01 vs. Water. n = 5–6 in each group.