Figure 2: rs55705857 is associated with IDH mutations and lower-grade in gliomas.
From: IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation
Stratification of gliomas by (a) grade and IDH mutation status, (b) molecular subtype that is based on IDH1/2 mutation, 1p/19q-codeletion, ATRX mutation status and grade. (square) indicates IDH-mutant tumors, (triangle) indicates IDH-wild-type tumors. Error bars indicate 95% confidence interval. Number of patients genotyped under each subtype is given on the left hand side and their genotype distribution on the right hand side, while the exact value of odds ratio is indicated above data points. (*) Indicates a statistical significance level of p < 0.05; (**) indicates a statistical significance level of p < 0.001; (***) indicates a statistical significance level of p < 0.0001. (c) 114 matched blood-tumor samples for genotyped for rs55705857 to exclude possible “Knudsonian second-hits”. 14 samples were of A/G genotype, 100 samples were of A/A genotype. y-axis indicates “%” concordance OR: odds ratio; n = number of patients.
