Figure 4: Transcriptional regulation analysis of LC-MS/MS comparison of WHO grade-II oligodendrogliomas and astrocytomas point to differential MYC network activity between rs55705857-G allele carriers and non-carriers.
From: IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation
Left panel: MetaCore transcriptional regulation analysis of differentially expressed proteins between A/G (n = 3) and A/A (n = 6) groups of IDH-mutant 1p/19q co-deleted ATRX-wt diffuse gliomas. Right panel: the same analysis was performed on LC-MS/MS data of IDH-mutant 1p/19q-intact ATRX-mut diffuse gliomas, A/G (n = 3) and A/A (n = 4) groups. “GO processes” and the particular p-value for each process is listed in the second column of each panel. zScore indicates the standard/normalized score for each transcription factor network analyzed.
