Figure 5: Metformin reduces airway bacterial load after wild type PAO1 infection in hyperglycaemic mice.
From: Increased airway glucose increases airway bacterial load in hyperglycaemia
Mice were injected with 2 doses of 10 mg/dose Streptozocin (STZ) intraperitoneally. On d-2, d-1 and d0 of infection, one group of mice received a 200 μl dose of 4 mg/ml i.p. metformin (MF). Blood glucose was measured before and after drug treatment (A). BAL glucose was measured after drug treatment (B). Mice were infected intranasally with 106 CFU/mouse of WT PAO1 and sacrificed after 24 hours. BAL CFU (C), neutrophilia (D) and IL-6 (E) were assessed at 24 hours after infection. Points represent individual mice. Lines represent mean values. *p < 0.05, calculated using multiple t tests with weighted corrections.
