Table 2 Cytoxicity values (MTT assay, see Methods) on HepG2 from saponins/sapogenins showing higher affinities.

From: Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin

Compd

IC50 [μM]

3

7.8 ± 0.3

6

3.5 ± 0.1

7

12.3 ± 0.2

8

20.2 ± 1.8

17

>100

18

4.1 ± 0.4

19

>100

  1. IC50 represents the concentration that reduces the cell viability by 50%.