Table 4 APOBEC overexpression correlation with PD-L1/PD-1 and OS.

Gene	MNC presence (score = 2, 3, 4)		PDL1 MNC presence (score = 2, 3, 4)		Longer OS			PDL1 tumor expression ( ≥ 5%)
Gene	P-vlaue		P-vlaue		HR, CI	P-vlaue		P-vlaue
APOBEC3A	0.007	High Expression	0.0009	High expression	0.45 (CI:0.23–0.86)	0.01	High expression	0.87
APOBEC3B	0.13		0.05	Low expression		0.89		0.18
APOBEC3C	0.80		0.2			0.6		0.06
APOBEC3D	0.05	High Expression	0.009	High expression	0.49 (0.25–0.95)	0.02	High expression	0.23
APOCEC3F_a	0.40		0.49			0.43		0.05	Low expression
APOBEC3F_b	0.46		0.31			0.15		0.04	Low expression
APOBEC3G	0.59		0.65			0.55		0.47
APOBEC3H	0.19		0.06	High expression	0.36 (0.19–0.71)	0.004	High expression	0.8

Correlation of APOBEC expression with OS was performed using a Cox regression model in multivariate analysis adjusting for ECOG PS and visceral disease. Wilcoxon’s non-parametric tests were used to summarize the associations of expression of APOBEC genes and PD-L1 expression on TIMCs and tumor cells. *HR: Hazard Ratio; *CI: Confidence Interval.

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