Table 4 ABCB11 polymorphisms in patients with and without ATDILI among different diagnoses of liver injury.
SNP | Model | Hepatocellular (N = 11) | Cholestatic/Mixed(N = 17) | Unclear (N = 61) | |||
|---|---|---|---|---|---|---|---|
OR(95%CI) | P value | OR(95%CI) | P value | OR(95%CI) | P value | ||
rs496550 | Dom | 0.53(0.14–1.98) | 0.345 | 1.53(0.49–4.74) | 0.461 | 0.93(0.53–1.66) | 0.814 |
Rec | 0.66(0.06–7.11) | 0.731 | 3.08(0.57–16.73) | 0.193 | 0.67(0.28–1.61) | 0.368 | |
Add | 0.64(0.23–1.79) | 0.394 | 1.61(0.70–3.70) | 0.263 | 0.88(0.58–1.33) | 0.538 | |
rs2287622 | Dom | 2.12(0.57–7.87) | 0.262 | 0.64(0.23–1.80) | 0.402 | 1.08(0.61–1.91) | 0.803 |
Rec | 3.56(0.20–64.34) | 0.391 | 0.48(0.05–4.23) | 0.506 | 1.59(0.53–4.77) | 0.411 | |
Add | 2.14(0.67–6.83) | 0.199 | 0.68(0.30–1.55) | 0.357 | 1.14(0.71–1.82) | 0.594 | |
rs3770592 | Dom | 1.02(0.25–4.16) | 0.975 | 0.94(0.31–2.89) | 0.911 | 1.06(0.60–1.88) | 0.848 |
Rec | NA | NA | NA | NA | NA | NA | |
Add | 0.85(0.24–3.07) | 0.807 | 0.83(0.31–2.20) | 0.702 | 1.08(0.66–1.75) | 0.769 | |
rs2287616 | Dom | 0.35(0.07–1.67) | 0.186 | 3.84(1.16–12.75) | 0.028 | 1.17(0.66–2.07) | 0.590 |
Rec | NA | NA | 3.27(0.68–15.73) | 0.140 | 1.85(0.71–4.79) | 0.206 | |
Add | 0.36(0.08–1.62) | 0.181 | 2.51(1.12–5.62) | 0.025 | 1.24(0.80–1.94) | 0.335 | |
