Figure 1 | Scientific Reports

Figure 1

From: LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo

Figure 1

Effect of LTP-1 on cell growth, viability and cell cycle progression in pancreatic cancer cells.

(A) Chemical structure of LTP-1. (B) Growth inhibition effect of LTP-1. Cells were incubated with or without LTP-1 at indicated concentration for 48 h and then cell growth were measured by SRB assay. Data represent at least three independent experiments. #P < 0.001 versus basal group; *P < 0.05; **P < 0.01; ***P < 0.001 versus control group. (C) Dose-dependent effect of LTP-1 on cell viability. Cells were incubated with or without LTP-1 at indicated concentration for 48 h and then cell viability were measured by MTT assay. ** or ##P < 0.01; *** or ###P < 0.001 compared with control group. Data represent mean ± S.E.M. of at least three independent experiments. (D,E) Time-dependent cell cycle progression effect of LTP-1 in pancreatic cancer cells. Cells were treated with 1 μM LTP-1 for indicated time interval and cell cycle distribution was analyzed by flow cytometry. Similar results were obtained in at least three independent experiments.

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