Figure 5 | Scientific Reports

Figure 5

From: LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo

Figure 5

Long-term treatment of LTP-1 induced polyploidy and apoptosis in human pancreatic cancer cells.

(A) LTP-1 induced polyploidy after long-term treatment of LTP-1. (B) Quantitative data of LTP-1-induced cell cycle distribution. Both cells were treated with LTP-1 for 96 or 168 h and cell cycles were analyzed by flow cytometry. (C) Long-term treatment of LTP-1 induced caspases and PARP activation. Both cells were treated with LTP-1 for 168 h and whole cell lysate were subjected to western blot analysis. Similar results were obtained in at least three independent experiments.

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