Figure 6: Dose-dependent relation between infection and inflammation across the consecutive sequence of evolutionary games.
Two infection-inflammation scenarios were simulated: low infection-dose in (a,c,e) and high infection-dose in (b,d,f). In (a,b) the distribution of infection scores and corresponding values for the normalised inflammation are shown as black histograms. The distribution of higher (lower) values for the normalised inflammation with NII→II ≥ 0.75 (NII→II < 0.75) are shown by circles colored in red (blue). The inflammatory signal NII→II was fed into Game II scaling AM activity. The effects of high and low values for the normalised inflammation are shown in (c,d) using red and blue inline histograms grouped by different levels of AM activity. The red and blue inline histograms were combined in the notched box plots and shown in orange, violet and green color, respectively, for low, medium and high AM activity with average values marked by (×). (e,f) Connection between Game II and Game III was set by the recruitment parameter ρPMN = NIII→III. Distributions for the different AM activities are presented in the same colors as in (d,e) grouped by PMN activities. The black short-dashed lines in (c–f) mark the infection score threshold IS = 0.25 below which clearance of infection is achieved.
