Table 5 Multivariate log-binomial regression analysis of clinical severity comparison between RSV-A ON1 and NA1 genotype ARI cases.

From: Association of RSV-A ON1 genotype with Increased Pediatric Acute Lower Respiratory Tract Infection in Vietnam

Clinical manifestation (s)

RSV (subgroup/genotype)

Unadjusted RR

95% CI

Adjusted RR †

95% CI

Vital sign

 SpO2 (≦90%)

RSV-A ON1 ARI group (n = 123)

5.05

1.11–22.92

3.18

0.71–14.29

 

RSV-A NA1 ARI group (n = 138) #

(ref.)

…

…

…

Clinical symptom and sign (s)

 Wheeze

 

2.44

1.90–3.13

2.21

1.72–2.86

 Tachypnea

 

1.99

1.42–2.78

1.83

1.30–2.57

 Difficulty breathing

 

2.87

1.38–5.96

2.46

1.12–5.39

 Crackle

 

2.06

1.35–3.15

1.96

1.28–3.00

 Chest-wall indrawing

 

1.78

0.90–3.51

1.95

0.88–4.31

LRTI and chest X-ray result

 LRTI§

 

2.24

1.41–3.57

2.26

1.37–3.72

Mild LRTI

 

2.37

1.11–5.04

1.94

0.90–4.19

Severe LRTI ƒ

 

2.15

1.12–4.14

2.42

1.12–5.25

 Abnormal chest X-ray

 

2.42

1.32–4.46

2.14

1.13–4.04

 Radiologically-confirmed pneumonia

 

2.25

1.18–4.30

1.98

1.01–3.87

  1. #In the log-binomial regression analysis, RSV-A NA1 ARI group (n = 138) was used as the reference group.
  2. 95% CI is abbreviation for 95% Confidence Interval.
  3. †In the multivariate log-binomial regression, variables including sex, age, antibiotic use prior to hospitalization, daycare attendance, viral co-infection and underlying medical condition were adjusted for estimating adjusted Relative Risk (Adj RR) and 95% Confidence Interval (CI).
  4. §LRTI is abbreviation for “lower respiratory tract infection” and based on the WHO definition of clinical pneumonia45.
  5. ƒSevere lower respiratory tract infection (LRTI) was defined as presence of either danger sign, stridor or chest-wall indrawing.
  6. All the statistically significant values were indicated in bold font.
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