Figure 1: The figure illustrates a summary of 15 SNPs within genes in the complement system and present on the ImmunoChip that were interrogated in The Environmental Determinants of Diabetes in the Young (TEDDY) study in 115 subjects that had developed type 1 diabetes versus all other subjects (n = 5359).

Subjects eligible for TEDDY carried any of the four high risk HLA-DR-DQ genotypes (DR3/4, 4/4, 4/8 or 3/3). The upper 95% confidence interval (CI) is indicated by the upper bar of the box, the lower. 95% CI is indicated by the lower bar of the box and the hazard ratio (HR) is indicated by a solid bar in the middle of the box. Three hazard ratios were different from 1.0 but only rs2230199 in C3 (p = 0.0002) among the DR4/4 carriers remained significant after Bonferroni correction since it was less than 0.000833 (0.05/60) in the HLA specific analyses. The explicit values of the HR (95% CI) for type 1 diabetes in the HLA stratified analyses can be found in an online Appendix. Panel A HRs and 95% CIs in 65 subjects with type 1 diabetes and 2139 subjects without type 1 diabetes carrying the HLA-DR3/4-genotype (n = 2204). Panel B HRs and 95% CIs in 19 subjects with type 1 diabetes and 1067 subjects without type 1 diabetes carrying the HLA DR4/4-genotype (n = 1086). Panel C HRs and 95% CIs in 16 subjects with type 1 diabetes and 950 subjects without type 1 diabetes carrying the HLA-DR4/8-genotype (n = 966). Panel D HRs and 95% CIs in 15 subjects with type 1 diabetes and 1203 subjects without type 1 diabetes carrying the HLA- DR3/3- genotype (n = 1218).