Table 5 Display of high risk HLA-genotypes constituting the criteria for eligibility for first degree relatives and children from the general population into The Environmental Determinants of Diabetes in the Young (TEDDY).

From: Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study

Code in

TEDDY

Genotypes

Abbreviation

General

population

A

DR3-DQA1*05:01-DQB1*02:01/

DR4-DQA1*03:0X-DQB1*03:02§

DR3/4

Yes

B

DR4-DQA1*03:0X-DQB1*03:02§/

DR4-DQA1*03:0X-DQB1*03:02§

DR4/4

Yes

C

DR4-DQA1*03:0X-DQB1*03:02§/

DR8-DQA1*04:01-DQB1*04:02

DR4/8

Yes

D

DR3-DQA1*05:01-DQB1*02:01/

DR3-DQA1*05:01-DQB1*02:01

DR3/3

Yes

E

DR4-DQA1*03:0X-DQB1*03:02§/

DR4-DQA1*03:0X-DQB1*02:01

DR4/4

No

F

DR4-DQA1*03:0X-DQB1*03:02§/

DR1#-DQA1*01:01-DQB1*05:01

DR4/1

No

G

DR4-DQA1*03:0X-DQB1*03:02§/

DR13-DQA1*01:02-DQB1*06:04

DR4/13

No

H

DR4-DQA1*03:0X-DQB1*03:02/

DR4-DQA1*03:01-DQB1*03:04

DR4/4

No

I

DR4-DQA1*03:0X-DQB1*03:02§/

DR9-DQA1*03:01-DQB1*03:03

DR4/9

No

J

DR3-DQA1*05:01-DQB1*02:01/

DR9-DQA1*03:01-DQB1*03:03

DR3/9

No

  1. §DR4 subtyping was performed to exclude children from the general population with DRB1*04:03. DQB1*03:04 also qualified for inclusion into the Environmental Determinants in the Young. Subtyping was not done to distinguish DQB1*02:0X and DQA1*03:0X subtypes. #In this DQB1*05:01 haplotype, DR10 had to be excluded, only DR1 was eligible. The asterisk (*) indicate that the alignment is unknown at any point.
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