Figure 2 | Scientific Reports

Figure 2

From: mTOR signalling in the nucleus accumbens shell is critical for augmented effect of TFF3 on behavioural response to cocaine

Figure 2

TFF3 administration potentiated the increment of the cocaine-induced hyperlocomotion activity and dopamine concentration in the NAc.

(A) Behavioural procedure. (B) TFF3 administration (0.1 mg/kg, i.p.) 30 min before cocaine injection significantly augmented cocaine-induced hyperlocomotion. (C) TFF3 administration (0.1 mg/kg, i.p.) 30 min before cocaine injection significantly promoted the cocaine-induced increase in dopamine concentration in the NAc. Data are expressed as the mean ± SEM. *p < 0.05, **p < 0.01 compared with “saline + saline” group; #p < 0.05 compared with “saline + cocaine” group. n = 6–12 per group.

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