Figure 4 | Scientific Reports

Figure 4

From: mTOR signalling in the nucleus accumbens shell is critical for augmented effect of TFF3 on behavioural response to cocaine

Figure 4

Inhibition of mTOR signalling in the NAc shell blocked the effect of TFF3 on cocaine-induced hyperlocomotion.

(A) Behavioural procedure. (B) Micro-injection of rapamycin into the NAc shell, (C) but not the core, prior to TFF3 administration blocked the increment of hyperlocomotion activity induced by TFF3 in cocaine-treated rats. Percentage of p-rpS6/rpS6 after the intra-NAc shell (D) or core (E) infusion of rapamycin prior to TFF3 administration NAc shell and core and the “vehicle + saline” group was used as the control. Rap: rapamycin. Data are expressed as the mean ± SEM., **p < 0.01, compared with “vehicle + saline” group; #p < 0.05 compared with “vehicle + TFF3” group. n = 6–11 per group.

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