Figure 2
From: Structure of neprilysin in complex with the active metabolite of sacubitril
Active site view of NEP in complex with LBQ657.
(a) Initial Fo-Fc difference electron density map for LBQ657 is shown in blue mesh. The map is contoured at 2.5 σ. (b) LBQ657 (yellow) makes H-bonding interactions (black dotted lines) with residues of NEP (white carbon atoms) and coordinates with zinc (pink). The active site surface of NEP is shown in grey.
