Figure 8 | Scientific Reports

Figure 8

From: Angiotensin-converting enzyme 2 prevents lipopolysaccharide-induced rat acute lung injury via suppressing the ERK1/2 and NF-κB signaling pathways

Figure 8

Effects of MAPKs inhibitors on LPS-induced lung cytokine secretion.

In LPS+ACE2-RNAi group, SB203580, PD98059 or SP600125 pretreatment significantly suppressed LPS-induced TNF-α and IL-1β secretion in rat BLAF. In Lenti-Ace2 infected rats, pretreatment with SB203580, PD98059 or SP600125 reversed the blockade effects of A779 or MLN4760 on ACE2 overexpression and markedly attenuated LPS-induced cytokine secretion in BALF. Data are represented as mean ± SD. *p < 0.05, versus control group; #p < 0.05, versus LPS group; $p < 0.05, versus (A,D) LPS+ACE2-RNAi group, (B,E) LPS+ACE2+A779 group, (C,F) LPS+ACE2+MLN4760 group (n = 6, per group).

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