Figure 4: Loss of asymmetric expression of Cerl2 in the node of Pierce1−/− embryos.
From: PIERCE1 is critical for specification of left-right asymmetry in mice
(A–H) The expression patterns of Cerl2 in the node of control and Pierce1−/− embryos with 3~5 somites were examined by whole-mount in situ hybridization using the Cerl2 antisense riboprobe. (A) In control embryos, the Cerl2 expression on the left-side of the node is down-regulated. (B–H) The right-side dominant expression of Cerl2 is not clearly observed in Pierce1−/− embryos (n = 7). All images are rear views. The orientation of the embryos is indicated by R (right) and L (left).
