Figure 1

HIF3A mRNA expression in human subcutaneous (SAT, n = 584) and visceral (VAT, n = 588) adipose tissue.

In the entire study cohort (A), but also in subgroups of men (SAT, n = 108; VAT, n = 110) and women (SAT, n = 231; VAT, n = 230) (Subjects with T2D were excluded from analysis) (B). Expression of HIF3A is significantly higher in subcutaneous (SAT) compared to visceral (VAT) adipose tissue. (C) HIF3A mRNA expression in adipocytes (n = 35) and cells of the stromal vascular fraction (SVF). HIF3A is significantly higher expressed in adipocytes compared to cells of the SVF in both compartments (D) HIF3A mRNA expression in relation to adipocyte cell size in subcutaneous (SAT) and visceral (VAT) adipose tissue. Individuals were categorized by mean SAT and VAT adipocyte size into deciles. Comparison of HIF3A mRNA expression between individuals with the lowest versus highest mean adipocyte size decile reveals that HIF3A is more highly expressed in subjects with higher mean adipocyte volume. Data are presented as means ± SEM. **p < 0.01, ***p < 0.001, AU-arbitrary units.