Figure 7

Model for Mid-mediated regulation of wing development.
Mid regulates wing development through repression of the Wg and Hh signaling in both tissue morphogenesis and cell adhesion. Mid represses the expression of wg to establish a proper expression level of Wg at the DV boundary. The repression of wg results in down-regulation of the downstream genes arm and DE-Cad, which affects the epithelial cell adhesion at adherens junction. By contrast, wg does not affect the expression of mid. Mid also represses the expression of hh to establish a proper expression level of Hh at the P compartment.