Figure 3 | Scientific Reports

Figure 3

From: IL-6 mediates differentiation disorder during spermatogenesis in obesity-associated inflammation by affecting the expression of Zfp637 through the SOCS3/STAT3 pathway

Figure 3

IL-6 can directly disrupt spermatogenesis by inhibiting the expression of Zfp637 in obese individuals.

The expressions of protamine 1 (A), TH2B (B) and Zfp637 (C) were measured by ICC, qRT-PCR and western blot, respectively, after a 48-h treatment with Leptin. (D) ELISA demonstrating elevated IL-6 levels in obese mice. (E) The expression levels of protamine 1, (F) TH2B and (G) Zfp637 measured by ICC-IF, qRT-PCR and western blot, respectively, after a 24-h treatment with IL-6.

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