Figure 4 | Scientific Reports

Figure 4

From: IL-6 mediates differentiation disorder during spermatogenesis in obesity-associated inflammation by affecting the expression of Zfp637 through the SOCS3/STAT3 pathway

Figure 4

IL-6 can directly disrupt spermatogenesis by inhibiting the expression of Zfp637 in obese individuals.

(A,B) Cell morphology and expression of protamine 1 in GC-1 spg cells transfected with pcDNA-Zfp637 and pcDNA-Vector, respectively, after a 24-h treatment with IL-6. (C,D) Cell morphology and expression of protamine 1 in GC-1 spg cells transfected with siRNA-Zfp637 and si-NC, respectively, after a 24-h treatment with IL-6.

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