Table 2 Genotypes of MTRR, MTHFR, MTR and TS polymorphism with gastric cancer patients’ survival in both cohorts.

From: The effects of genomic polymorphisms in one-carbon metabolism pathways on survival of gastric cancer patients received fluorouracil-based adjuvant therapy

Genetic model

Genotypes

Chemotherapy

No chemotherapy

MST (mouths)

P

HR (95% CI) a

MST (mouths)

p

HR (95% CI) a

MTRR rs1801394 66 A > G

 Codominant model

AA

46

0.089

1

38

0.419

1

 

GA

72 b

0.675 (0.452–1.007)

62

0.880 (0.659–1.176)

 

GG

85 b

0.526 (0.192–1.443)

62

0.683 (0.347–1.344)

 Dominant model

GA/GG

80 b

0.031

0.657 (0.446–0.967)

62

0.853 (0.645–1.129)

TYMS 5-UTR 2R > 3R

 Codominant model

2R2R

23

0.024

1

60 b

0.600

1

 

2R3R

51

0.629 (0.312–1.268)

50

1.433 (0.658–3.124)

 

3R3R

70 b

0.435 (0.221–0.857)

50

1.474 (0.687–3.164)

 Dominant model

2R3R/3R3R

73 b

0.032

0.498 (0.259–0.960)

50

0.320

1.459 (0.685–3.106)

 Recessive model

2R2R/2R3R

39

0.022

1

56

0.643

1

 

3R3R

70 b

0.637 (0.430–0.944)

50

1.071 (0.800–1.433)

MTHFR rs1801131 1298 A > C

 Codominant model

AA

62

0.55

1

48

0.739

1

 

CA

72 b

1.011 (0.656–1.559)

48

1.012 (0.747–1.371)

 

CC

69 b

0.471(0.116–1.918)

68 b

0.585 (0.145–2.362)

 Dominant model

CA/CC

75 b

0.771

0.940 (0.616–1.433)

48

0.934

0.987 (0.732–1.333)

MTHFR rs1801133 677C > T

 Codominant model

CC

72 b

0.697

1

38

0.610

1

 

TC

59 b

1.169 (0.771–1.774)

43

0.973 (0.694–1.266)

 

TT

55

0.983 (0.555–1.741)

63

0.814 (0.541–1.226)

 Dominant model

TC/TT

60 b

0.587

1.118 (0.753–1.659)

48

0.904 (0.679–1.203)

MTR rs1805087 2756 A > G

 Codominant model

AA

62

0.613

1

53

0.059

1

 

GA

73

0.943 (0.559–1.591)

42

1.3699 (0.957–1.958)

 

GG

0

0

 

0

 Dominant model

GA/GG

64 b

0.681

0.897 (0.532–1.513)

26

0.205

1.257 (0.879–1.797)

TYMS 3-UTR 6bp ins > del

 Codominant model

I/I

46

0.171

1

55 b

0.811

1

 

D/I

50

1.028 (0.539–1.961)

47

1.207 (0.677–2.151)

 

D/D

71 b

0.703 (0.359–1.376)

50

1.192 (0.668–2.128)

 Dominant model

DI/DD

72 b

0.654

0.868 (0.456–1.620)

48

0.521

1.200 (0.684–2.104)

  1. aAdjusted for age and sex.
  2. bMean survival time was provided when MST could not be calculated.
  3. 2R, 2-repeat; 3R, 3-repeat; I, 6-bp insertion; D; 6-bp deletion; P, Log-rank p.
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