Table 3 Stratified analysis of the MTRR 66A > G polymorphism with gastric cancer overall survival in patients received adjuvant chemotherapy.
Variables | Genotypes (Dominant model) | MST (AA/GA + GG) | HR (95% CI) a | P Heterogeneity | |
|---|---|---|---|---|---|
AA | GA/GG | ||||
Total | 136/69 | 113/41 | 46/80 b | 0.657 (0.446–0.967) | 0.031 |
Age | |||||
≤60 | 73/35 | 69/25 | 52/73 b | 0.697 (0.416–1.165) | 0.163 |
>60 | 63/34 | 44/16 | 42/79 b | 0.622 (0.343–1.127) | 0.109 |
Tumor size | |||||
≤5 cm | 77/38 | 64/21 | 46/84 b | 0.607 (0.356–1.036) | 0.062 |
>5 cm | 59/31 | 49/20 | 51/67 b | 0.725 (0.413–1.273) | 0.255 |
Tumor site | |||||
Non-cardia | 88/44 | 68/25 | 43/72 b | 0.645 (0.394–1.054) | 0.076 |
Cardia | 48/25 | 45/16 | 51/80 b | 0.700 (0.373–1.311) | 0.259 |
Histological type | |||||
Intestinal type | 40/20 | 32/15 | 51/58 b | 0.891 (0.456–1.743) | 0.734 |
Diffuse type | 96/49 | 81/26 | 43/83 b | 0.573 (0.356–0.923) | 0.019 |
Tumor differentiation | |||||
Well to moderately | 37/19 | 30/14 | 46/57 b | 0.864 (0.433–1.724) | 0.676 |
poor | 80/40 | 71/19 | 50/89 b | 0.460 (0.266–0.795) | 0.004 |
mucinous /signet-ring cell | 19/10 | 12/8 | 43/20 | 1.514 (0.592–3.871) | 0.382 |
Depth of invasion | |||||
T1/T2 | 8/5 | 16/8 | 24/56 b | 0.681 (0.222–2.088) | 0.495 |
T3/T4 | 128/64 | 97/33 | 50/82 b | 0.631 (0.414–0.961) | 0.029 |
Lymph node metastasis | |||||
N0 | 29/10 | 22/8 | 70b/65 b | 1.276 (0.502–3.244) | 0.606 |
N1/N2/N3 | 107/59 | 91/33 | 39/80 b | 0.562 (0.367–0.863) | 0.007 |
Distant metastasis | |||||
M0 | 136/69 | 113/41 | 46/80 b | 0.657 (0.446–0.967) | 0.031 |
TNM stage | |||||
II | 36/15 | 35/14 | 62/63 b | 1.073 (0.517–2.226) | 0.849 |
III | 100/54 | 78/27 | 39/81 b | 0.557 (0.350–0.885) | 0.011 |
