Figure 3 | Scientific Reports

Figure 3

From: Characterisation of light responses in the retina of mice lacking principle components of rod, cone and melanopsin phototransduction signalling pathways

Figure 3

Light-induced c-fos expression in the TKO retina following white light and UV light stimuli.

(A,B) Levels of light-induced c-fos observed in the TKO retina following white light (14.7 log photons/cm2/s for 30 mins at ZT16) and UV light pulses (12.7 log photons/cm2/s). (C) Graph showing the density of c-fos positive cells detected in the TKO retina following white light and UV light pulses. * Indicates p = 7.3E-8. (D) Individual confocal slices (2.5 μm in z-axis) showing the distribution of c-fos positive cells (red) in the ganglion cell layer (GCL) and inner nuclear layer (INL) of the TKO retina. Labelling of M1-type pRGCs (green) (via β-gal labelling of tauLacZ reporter incorporated into TKO mice) that project to the INL is shown to confirm the location of cells on the innermost surface of the INL. Location of the ganglion cell layer (GCL), inner plexiform layer (IPL) and inner nuclear layer (INL), as well as the depth from the GCL are indicated by the relevant labels.

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