Table 1 Comparison of human immune cell function in HLA-Tg humanized mice vs non-Tg mice.

Mouse strain	HLA transgene	Age	Radiation dose (Rads)	Route	Source of HSC	^# HSC injected	Improvement of				Ref. ^#
Mouse strain	HLA transgene	Age	Radiation dose (Rads)	Route	Source of HSC	^# HSC injected	T cell reconstitution	Polyclonal T cell cytokine response (stimulator)	HLA-restriction	Ig class switching	Ref. ^#
NSG	A*2.01-Tg (HHD)	newborn	150	i.v.	CD34 cord blood	5–30 × 10³	No	No (PMA/Iono)	Yes	NR	6
		adult	240		T-cell depleted cord blood	3 × 10⁴	NR	NR	Yes	No	7
		adult	300		CD34 bone marrow	4.6 × 10⁵	No	NR	Yes	NR	8
	A*2.01-Tg (Enge)	newborn	200	i.h.	CD34 cord blood	1 × 10⁵	No ^#	NR	NR	NR	9
	A*2.01-Tg (Enge)	newborn	100		CD34 fetal liver	1–3 × 10⁵	No	No (SEB)	Yes	No	10
NOK^&	B*51.1-Tg	newborn	NR		CD34 cord blood	5–10 × 10⁴	No^&	NR	NR	NR	11
NRG	DR*0401-Tg	adult	350	i.v.		1 × 10⁵	Yes	Yes (PMA/Iono) Yes CD3/CD28)	NR	Yes	12
NOG	DR*0405-Tg Ab⁰	adult	120	i.v.		1 × 10⁵	Yes	Yes (PMA/Iono)	NR	Yes	13
NSG	DR*0101-Tg Ab⁰	newborn	150	i.h.		3–5 × 10⁴	Yes	Yes (PMA/Iono)	NR	Yes	14
NSG	A2.01-Tg (Enge) DR0101-Tg	newborn	100	i.h.	CD34 fetal liver	1.5–2 × 10⁵	No	Yes (PMA/Iono)	Yes	Very low	15

NSG, NOD.scid.IL2RgcKO (complete IL2Rγc mutation); NOG, NOD.scid.IL2RgcKO (truncated IL2Rγc mutation). NRG, NOD.Rag1KO.IL2RγcKO (complete IL2Rγc mutation); NOK, NOD.scid.Jak3KO; HHD, hybrid human/mouse HLA-A2.1/H2D^b covalently linked to human β2 m; Enge, human HLA-A2.1; Ab⁰, mouse MHC-II KO; i.v., intravenous; i.h., intrahepatic; NR, not reported; (^#) this study showed lower human T cell reconstitution rate in HLA-A2-Tg NSG mice as compared to NSG mice; (^&) No HLA genotyping was performed on cord bloods used for this study.

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