Figure 1: Proposed pathway for fructose-asparagine (F-Asn) utilization in Salmonella enterica and genetic organization of the fra island. | Scientific Reports

Figure 1: Proposed pathway for fructose-asparagine (F-Asn) utilization in Salmonella enterica and genetic organization of the fra island.

From: A metabolic intermediate of the fructose-asparagine utilization pathway inhibits growth of a Salmonella fraB mutant

Figure 1

The five fra genes are unique to Salmonella while the surrounding treF and gor genes are conserved between E. coli and Salmonella. A proteomic survey of subcellular fractions determined that FraE is periplasmic while FraB is cytoplasmic33. The functions of FraD and FraB were proposed based on homology to the E. coli FrlD and FrlB proteins involved in fructose-lysine metabolism18, and the inability of a fraB mutant to grow on F-Asn16. In this report, we confirm that 6-phosphofructose-aspartate (6-P-F-Asp) is the product of FraD and the substrate of FraB.

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