Table 1 Effects of FSH (24 hr.) or PKA-CQR (24 hr.) on transcripts associated with GC steroidogenesis, differentiation and ovulation.
From: Protein Kinase A: A Master Kinase of Granulosa Cell Differentiation
Symbol | Entrez Gene Name | FSH/Con | PKA/Con | FSH/PKA |
|---|---|---|---|---|
Genes involved in steroidogenesis | ||||
Srebf1 | sterol regulatory element binding transcription factor 1 | 2.28 | 1.8 | 1.26 |
Star | steroidogenic acute regulatory protein | 14.13 | 9.11 | 1.55 |
Cyp19a1 | cytochrome P450, family 19, subfamily A, polypeptide 1 | 29.44 | 59.71 | 0.49 |
Cyp11a1 | cytochrome P450, family 11, subfamily A, polypeptide 1 | 51.31 | 36.4 | 1.41 |
Por | P450 (cytochrome) oxidoreductase | 2.3 | 1.95 | 1.18 |
Genes involved in differentiation | ||||
Egfr | epidermal growth factor receptor | 2.03 | 2.04 | 1 |
Lhcgr | luteinizing hormone/choriogonadotropin receptor | 27.99 | 41.79 | 0.67 |
Prlr | prolactin receptor | 5.44 | 4.08 | 1.33 |
Ctgf | connective tissue growth factor | 0.59 | 0.82 | 0.73 |
Inha | inhibin, alpha | 2.43 | 2.41 | 1.01 |
Inhba | inhibin, beta A | 2.77 | 2.5 | 1.11 |
Inhbb | inhibin, beta B | 3.43 | 3.35 | 1.02 |
Transcriptional regulators involved in GC differentiation | ||||
Nr0b2 | nuclear receptor subfamily 0, group B, member 2 | 2.77 | 1.67 | 1.66 |
Nr5a1 | nuclear receptor subfamily 5, group A, member 1 | 2.36 | 2.05 | 1.15 |
Nr5a2 | nuclear receptor subfamily 5, group A, member 2 | 2.35 | 1.88 | 1.25 |
Nr1h3 | nuclear receptor subfamily 1, group H, member 3 | 2.44 | 1.98 | 1.23 |
Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 2.02 | 1.77 | 1.14 |
Giot1 | Zfp932 | 5.71 | 6.07 | 0.94 |
Gata4 | GATA binding protein 4 | 2.31 | 2.25 | 1.02 |
Nr0b1 | nuclear receptor subfamily 0, group B, member 1 | −5.93 | −1.83 | 3.24 |
Foxo1 | forkhead box O1 | −2.13 | −1.41 | 1.51 |
Tead3 | TEA domain family member 3 | −2.06 | −1.75 | 1.18 |
Genes involved in ovulation | ||||
Areg | amphiregulin | 3.57 | 13.84 | 0.26 |
Ereg | epiregulin | 5.37 | 18.1 | 0.3 |
Pgr | progesterone receptor | 1.74 | 4.29 | 0.41 |
Snap25 | synaptosomal-associated protein 25Kda | 1.6 | 2.57 | 0.62 |
Tnfaip6 | tumor necrosis factor, alpha-induced protein 6 | 30.15 | 46.64 | 0.65 |
Ptgs2 | prostaglandin-endoperoxide synthase 2 | 12.77 | 35.2 | 0.36 |
