Figure 2: BAPN treatment, without Ang II infusion, induced TAD in C57BL/6 mice, reproducing major features of human TAD. | Scientific Reports

Figure 2: BAPN treatment, without Ang II infusion, induced TAD in C57BL/6 mice, reproducing major features of human TAD.

From: β-Aminopropionitrile monofumarate induces thoracic aortic dissection in C57BL/6 mice

Figure 2

(a) Representative images showing macroscopic features of isolated mouse aorta after vehicle or BAPN treatment for 4 wk; white arrow indicates location of TAD. (b) Representative haematoxylin and eosin (HE) staining showing blood clot inside torn aortic wall after BAPN administration. (c) Representative Elastica Van Gieson (EVG) staining presenting elastic fragmentation and loss of smooth muscle cells after BAPN administration. Representative HE (d) and EVG (e) staining in human samples. Scale bar: 50 μm.

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