Figure 1: Secondary structure and activity of an HDV-like ribozyme with a structured J1/2-P1.2 domain.

(a) A. gambiae Agam-2-1 HDV-like ribozyme. The catalytic core of the ribozyme is boxed in grey, the RNA self-cleaves at its 5′ terminus. (b) Log-log plot of Mg²⁺-dependence of the ribozyme reveals a Hill coefficient of 1.06 (see Materials and Methods).