Figure 3
In vitro cellular uptake assay, targeted MR and CT imaging and photothermal ablation of HeLa cells.
(a) The Au uptake by HeLa-HFAR and HeLa-LFAR cells after treated with the Fe3O4 @ Au-PEI.Ac-PEG-FA NSs at various Au concentrations for 4 h. TEM images of (b) HeLa-HFAR and (c) HeLa-LFAR cells after treated with the Fe3O4 @ Au-PEI.Ac-PEG-FA NSs for 4 h, respectively. (d) T2-weighted MR images, (e) MR signal intensity, (f) CT images and (g) CT value of HeLa-HFAR and HeLa-LFAR cells treated with the Fe3O4 @ Au-PEI.Ac-PEG-FA NSs at varying Fe or Au concentrations for 6 h. (h) MTT assay of HeLa cell viability after treatment with the Fe3O4 @ Au-PEI.Ac-PEG-FA NSs in a given Au concentration range under an 808 nm laser irradiation for 5 min. 1 and 2 represent the HeLa-LFAR and HeLa-HFAR cells, respectively.
