Figure 7 | Scientific Reports

Figure 7

From: The chimeric ubiquitin ligase SH2-U-box inhibits the growth of imatinib-sensitive and resistant CML by targeting the native and T315I-mutant BCR-ABL

Figure 7

Working model of SH2-U-box.

The chimeric ubiquitin ligase SH2-U-box is able to interact with BCR-ABL and BCR-ABL T315I, promoting their ubiquitination and subsequent degradation. As a result, SH2-U-box attenuates BCR-ABL-dependent pathway, inhibits the proliferation and induces the apoptosis of imatinib- sensitive and resistant CML cells.

Back to article page