Table 2 Coding variants associated with QT interval in EA ARIC subjects.

Chr:Position (hg19)	Gene	cDNA change	Protein change	MAF	Beta	P	PhyloP score	Protein domain	ExAC allele count
2:179455718	TTN	c.G60734A	p.R20245Q	0.00011	8.78	1.22 × 10⁻¹⁸	6.39	FN2	4/120604
2:179407497	TTN	c.G97084T	p.A32362S	0.00011	5.39	6.89 × 10⁻⁸	0.15	–	–
2:212522534	ERBB4	c.C1891T	p.H631Y	0.00022	3.69	1.73 × 10⁻⁷	4.15	–	–
2:179634919	TTN	c.A8509T	p.S2837C	0.00022	3.19	6.43 × 10⁻⁶	3.73	IG	12/121362
2:179473995	TTN	c.A52042G	p.M17348V	0.00011	4.14	3.33 × 10⁻⁵	1.38	FN3	2/96388
2:179398282	TTN	c.C103060T	p.P34354S	0.00011	4.14	3.47 × 10⁻⁵	5.98	–	–
2:179629385	TTN	c.A9857G	p.K3286R	0.00011	4.11	3.81 × 10⁻⁵	5.11	IGC2	15/121360
2:179496930	TTN	c.C43691G	p.S14564C	0.00011	4.11	3.98 × 10⁻⁵	6.35	–	5/81630
2:179466803	TTN	c.C55195T	p.P18399S	0.00011	3.88	0.00010	4.14	FN3	1/120260
8:13959964	SGCZ	c.G665T	p.G222V	0.00011	3.78	0.00015	5.48	–	–
2:179424880	TTN	c.T85979C	p.I28660T	0.00011	3.77	0.00016	5.31	IGC2	2/120508
2:179413763	TTN	c.G92590A	p.D30864N	0.00011	3.66	0.00025	3.76	FN3	16/120638
2:179486250	TTN	c.A45301C	p.N15101H	0.00011	3.62	0.00029	3.60	–	–
2:179644182	TTN	c.A3737T	p.H1246L	0.00011	3.63	0.00029	3.43	–	–
3:38592534	SCN5A	c.G5326A	p.V1776M	0.00011	3.62	0.00029	5.80	–	3/121080
2:179666975	TTN	c.G185A	p.R62H	0.00011	3.56	0.00037	6.21	IGC2	15/121364

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