Table 3 Coding variants associated with QT interval in AA ARIC subjects.

Chr:Position (hg19)	Gene	cDNA change	Protein change	MAF	Beta	P	PhyloP score	Protein domain	ExAC allele count
9:35711334	TLN1	c.A3937G	p.S1313G	0.00026	15.81	3.60 × 10⁻⁶⁰	3.48	–	2/121374
2:179455331	TTN	c.C61121T	p.P20374L	0.00053	8.85	2.26 × 10⁻³⁷	6.39	–	2/119910
2:179447784	TTN	c.C65746T	p.R21916W	0.00026	4.98	5.87 × 10⁻⁰⁷	0.65	IGC2	13/113940
3:38645514	SCN5A	c.G1579A	p.G527R	0.00026	4.33	1.48 × 10⁻⁰⁵	3.93	–	4/90200
2:179528396	TTN	c.C36490A	p.P12164T	0.00026	4.10	4.03 × 10⁻⁰⁵	−0.49	IG	7/117870
2:179447313	TTN	c.C65870T	p.P21957L	0.00026	3.90	9.92 × 10⁻⁰⁵	6.22	FN3	–
2:179428672–179428673	TTN	c.82186_82187CA > GT	p.Q27396V	0.00026	3.79	0.00015	4.74, 5.31	FN3	1/120622, 1/120618
2:179451505	TTN	c.G64123A	p.V21375M	0.00026	3.79	0.00015	6.37	FN3	1/120562
2:179497341	TTN	c.G43392A	p.M14464I	0.00026	3.79	0.00015	1.68	IGC2	3/120562
2:179434555	TTN	c.G76304A	p.C25435Y	0.00026	3.62	0.00029	4.48	IGC2	1/120440
2:179440480	TTN	c.T70379G	p.L23460R	0.00053	2.52	0.00036	5.13	FN3	–

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