Figure 1: Power comparison given the same source population for trios and controls (larger proportion of causal variants). | Scientific Reports

Figure 1: Power comparison given the same source population for trios and controls (larger proportion of causal variants).

From: Conditioning adaptive combination of P-values method to analyze case-parent trios with or without population controls

Figure 1

The figure shows the empirical power given the nominal significance level of 0.05. Top row: all causal variants were deleterious; bottom row: 50% of causal variants were deleterious and 50% were protective. The x-axis is the number of population controls, whereas the y-axis is the power. The study subjects (including trio members and population controls) comprised 0:100 (the left column, all were Africans), 20:80 (the second column), 50:50 (the middle column), 80:20 (the fourth column), and 100:0 (the right column, all were Europeans) ratios of Europeans to Africans, respectively.

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