Figure 5: Microarray assay in WT and CHIP-TG hearts after DOX treatment. | Scientific Reports

Figure 5: Microarray assay in WT and CHIP-TG hearts after DOX treatment.

From: Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting protein

Figure 5

(a) Hierarchical clustering depicting expression profiles of differentially expressed genes in WT and CHIP-TG mice on day 5 after saline/DOX treatment (n = 3 per group). Gene expression levels are shown as color variations (red, high expression; green, low expression). (b) The significant different GO of up-regulated (above) and down-regulated (below) between WT and CHIP-TG mice-treated with DOX. (c) The primary microarray data showed fold change of the selected genes expression in WT and CHIP-TG mice-treated with DOX. (n = 6 per group). (d) qPCR validation for the selected genes mRNA levels in WT and CHIP-TG mice-treated with DOX. (n = 6 per group).

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